Exposure to early life adversity alters the future behavioral response to a stressful challenge in BALB/C mice

Abstract

Depression is considered as a maladaptive response to stress in adult life. Exposure to stress in early childhood is recognized as a risk factor for being unable to adapt to environmental changes in adult life. Early life stress (ELS) has been modelled in animals to help understand the behavioral outcome of the adversity. Periodic maternal separation (MS) in rodents for the first two weeks of life is one such model. We used MS as a form of ELS in Balb/c mice to study its effect on a stressful challenge encountered in adult life. According to our results, exposure to MS predisposed mice to an altered behavioral response. However, this response was not worsened by exposure to restraint stress (RS) experienced in early adult life. This controversy may be attributed to methodological and biological variations among animals as well as humans.