Abstract
It is widely assumed that inositol trisphosphate (IP3) and ryanodine (Ry) receptors share the same Ca2+ pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP3- and Ry-receptors are associated with two functionally distinct intracellular Ca2+ stores, respectively. While the IP3-sensitive Ca2+ store refilling requires Orai2 channels, Ry-sensitive Ca2+ store refilling involves voltage-gated Ca2+ channels (VGCCs). Our findings have direct implications for the understanding of function and plasticity in these central mammalian neurons.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcium / metabolism*
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Calcium Channels
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Gene Expression Regulation
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Hippocampus / metabolism*
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Inositol Phosphates / metabolism
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Ions
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Mice
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Mice, Knockout
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Models, Animal
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ORAI2 Protein / genetics
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ORAI2 Protein / metabolism*
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Pyramidal Cells / metabolism*
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Ryanodine Receptor Calcium Release Channel / metabolism
Substances
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Calcium Channels
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Inositol Phosphates
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Ions
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ORAI2 Protein
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Orai2 protein, mouse
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Ryanodine Receptor Calcium Release Channel
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inositol trispyrophosphate
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Calcium