No Bones About It: Small Molecules for Bone Regeneration

Jae Won Chang; Raymond E Moellering

doi:10.1016/j.chembiol.2019.06.007

No Bones About It: Small Molecules for Bone Regeneration

Cell Chem Biol. 2019 Jul 18;26(7):911-912. doi: 10.1016/j.chembiol.2019.06.007.

Authors

Jae Won Chang¹, Raymond E Moellering²

Affiliations

¹ Department of Chemistry, University of Chicago, Chicago, IL 60637, USA; Institute for Genomics and Systems Biology, University of Chicago, IL 60637, USA.
² Department of Chemistry, University of Chicago, Chicago, IL 60637, USA; Institute for Genomics and Systems Biology, University of Chicago, IL 60637, USA. Electronic address: rmoellering@uchicago.edu.

PMID: 31323220
DOI: 10.1016/j.chembiol.2019.06.007

Abstract

In this issue of Cell Chemical Biology, Cook et al. (2019) report a new small-molecule activator that enhances osteogenesis and skeletal regeneration in developmental and adult animal models, respectively. This discovery has therapeutic potential for healing following traumatic bone injury, as well as bone remodeling in response to osteoporosis.

Publication types

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MeSH terms

Animals
Bone Regeneration*
Cell Differentiation
Humans
Mice
Osteoblasts
Osteogenesis*
p38 Mitogen-Activated Protein Kinases

Substances

p38 Mitogen-Activated Protein Kinases