Interactome Changes Quantified to Identify the ER Proteostasis Network to Fight Amyloid Diseases

Ya-Juan Wang; Ting-Wei Mu

doi:10.1016/j.chembiol.2019.07.003

Interactome Changes Quantified to Identify the ER Proteostasis Network to Fight Amyloid Diseases

Cell Chem Biol. 2019 Jul 18;26(7):909-910. doi: 10.1016/j.chembiol.2019.07.003.

Authors

Ya-Juan Wang¹, Ting-Wei Mu²

Affiliations

¹ Department of Translational Medicine, Merck & Co., Kenilworth, NJ 07033, USA.
² Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: tingwei.mu@case.edu.

Abstract

In this issue of Cell Chemical Biology, Plate et al. (2019) used quantitative interactome proteomics to define the molecular mechanism by which ATF6 activation reduces amyloidogenic protein secretion. These results shed light on preventing the amyloid formation at the very early step to treat devastating amyloid diseases.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Amyloid
Amyloidogenic Proteins
Proteomics*
Proteostasis*

Substances

Amyloid
Amyloidogenic Proteins

Grants and funding

R01 NS105789/NS/NINDS NIH HHS/United States