Cobalt (II) phthalocyanine embedded with ganciclovir units has been synthesized by a novel method using tetracarboxylic phthalocyanine reported for the first time. The synthesized dark green colored complexes were characterized by electronic spectroscopy, elemental analysis, FT-IR, MASS and XRD. Thermal stability study reveals that the newly synthesized complex was stable up to 300 °C and XRD patterns showed amorphous nature of the complex. In the present work, the synthesized complex was characterized by cyclic voltammetry and shows the redox behavior corresponding to central metal (Co+II/Co+I) of the complex. Three biomolecules are well-separated by their oxidation peaks in simultaneous determination predicting the potentials for (-128, 335, and 723 mV) with highly increasing current. The low detection limit of AA, DA, and UA were 0.33, 0.03 and 0.10 μmol by CV method and good responses of amperometric and DPV technique. The modified tetra substituted CoTGPc/GCE exhibit an excellent electrocatalytic activity, stability, high sensitivity, good linearity, and selectivity without losing its catalytic activity and proves to be a versatile chemical sensor for commercial pharmaceutical samples, vitamin C tablets, and dopamine injections.
Keywords: Amperometry sensors; Analytical chemistry; Ascorbic acid; CoTGPc; Dopamine; Electrochemistry; Uric acid.