Physicochemical data of oleic acid-poloxamer organogel for intravaginal voriconazole delivery

Samyr M Querobino; Naially C de Faria; Aryane A Vigato; Bruna G M da Silva; Ian P Machado; Maricilia S Costa; Fanny N Costa; Daniele R de Araujo; Carlos Alberto-Silva

doi:10.1016/j.dib.2019.104180

Physicochemical data of oleic acid-poloxamer organogel for intravaginal voriconazole delivery

Data Brief. 2019 Jun 24:25:104180. doi: 10.1016/j.dib.2019.104180. eCollection 2019 Aug.

Authors

Samyr M Querobino¹, Naially C de Faria², Aryane A Vigato², Bruna G M da Silva³, Ian P Machado⁴, Maricilia S Costa³, Fanny N Costa², Daniele R de Araujo², Carlos Alberto-Silva⁵

Affiliations

¹ Universidade do Estado de Minas Gerais - UEMG, Av. Juca Stockler, 1130, Bairro Belo Horizonte, Passos, 37900-106, MG, Brazil.
² Natural and Human Sciences Center, Federal University of ABC (UFABC), Av. dos Estados, n° 5001, Bloco A, Torre 3, Lab 503-3, Santo André, SP, Brazil.
³ Instituto de Pesquisa e Desenvolvimento - IP&D, Universidade do Vale do Paraíba (UNIVAP), Av. Shishima Hifumi, n° 2911, São José dos Campos, SP, Brazil.
⁴ Department of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, 05588-000, SP, Brazil.
⁵ Natural and Human Sciences Center, Federal University of ABC (UFABC), Rua Arcturus, n° 03, Bloco Delta, São Bernardo do Campo, 09606-070, SP, Brazil.

Abstract

Functional polymeric nanoparticles have attracted attention for different biomedical applications, including drug delivery. Poloxamers (PL), a synthetic copolymers of poly(ethyleneoxide)-b-poly(propylene oxide)-b-poly(ethylene oxide), that exhibit thermoreversible behavior in aqueous solutions. Physicochemical properties of Oleic Acid-Poloxamer (OA-PL) organogel for intravaginal controlled Voriconazole (VRC) delivery were assessed using three different oils (isopropyl myristate - IPM, isopropyl palmitate - IPP, and oleic acid - OA, in order to select the most suitable oil phase for increasing the solubility of the drug and its dispersion in the final aqueous phase. Organogel structural organization was assessed by VRC partition coefficient, differential scanning calorimetry (DSC), rheological analysis, and drug release assay. These data are complementary to the research article entitled "Sodium alginate in oil-poloxamer organogels for intravaginal drug delivery: influence on structural parameters, drug release mechanisms, cytotoxicity and in vitro antifungal activity" - Materials Science and Engineering: C, 2019. 99: p. 1350-1361.

Keywords: Oleic acid; Organogel; Poloxamer; Sodium alginate; Vaginal release; Voriconazole.