Retinal imaging has undergone a revolution in the past 50 years to allow for better understanding of the eye in health and disease. Significant improvements have occurred both in hardware such as lasers and optics in addition to software image analysis. Optical imaging modalities include optical coherence tomography (OCT), OCT angiography (OCTA), photoacoustic microscopy (PAM), scanning laser ophthalmoscopy (SLO), adaptive optics (AO), fundus autofluorescence (FAF), and molecular imaging (MI). These imaging modalities have enabled improved visualization of retinal pathophysiology and have had a substantial impact on basic and translational medical research. These improvements in technology have translated into early disease detection, more accurate diagnosis, and improved management of numerous chorioretinal diseases. This article summarizes recent advances and applications of retinal optical imaging techniques, discusses current clinical challenges, and predicts future directions in retinal optical imaging.
Keywords: adaptive optics (AO); age-related macular degeneration (AMD); choroidal neovascularization (CNV); diabetic retinopathy (DR); fundus autofluorescence; molecular imaging; optical coherence tomography (OCT); optical coherence tomography angiography (OCTA); optical imaging; photoacoustic microscopy; retina; retinal vein occlusions (RVO); scanning laser ophthalmoscopy (SLO).