Sleep-disordered breathing: an under-recognized problem in infants with myelomeningocele defects regardless of timing of repair

J Perinatol. 2019 Oct;39(10):1411-1416. doi: 10.1038/s41372-019-0433-7. Epub 2019 Jul 18.

Abstract

Objective: To evaluate the prevalence of sleep-disordered breathing (SDB) in infants with myelomeningocele (MMC) and the effect of fetal repair on SDB.

Study design: We conducted a retrospective cohort study of infants with MMC admitted to a pediatric hospital (2007-2017). Pneumocardiogram (PCG) results, a measure of SDB, were compared between infants who underwent fetal MMC (fMMC) versus postnatal MMC repair.

Result: Of 118 eligible infants, 17 (14%) underwent fetal repair. Of these, 106 (90%) had PCG studies; abnormal PCG results were common but not different between fMMC (n = 12, 92%) and postnatal repair groups (n = 72, 77%, p = 0.22). Among infants with abnormal results, central apnea events >10 s (median 16 vs. 3 events, p = 0.02) and percentage of time spent in periodic breathing (median 15% vs. 7%, p = 0.01) were greater in the fMMC group.

Conclusion: SDB was common among all MMC infants regardless of repair timing, indicating a need for standard screening recommendations.

Publication types

  • Comparative Study

MeSH terms

  • Female
  • Fetal Diseases / surgery*
  • Fetal Therapies*
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / surgery
  • Logistic Models
  • Male
  • Meningomyelocele / complications*
  • Meningomyelocele / surgery
  • Prevalence
  • Retrospective Studies
  • Sleep Apnea Syndromes / epidemiology
  • Sleep Apnea Syndromes / etiology*
  • Time Factors