Whole Genome Mate-pair Sequencing of Plasma Cell Neoplasm as a Novel Diagnostic Strategy: A Case of Unrecognized t(2;11) Structural Variation

Jess F Peterson; Reid G Meyer; Stephanie A Smoley; Matthew Webley; James B Smadbeck; George Vasmatzis; Kathryn Pearce; Patricia T Greipp; Rhett P Ketterling; Fiona E Craig; A Keith Stewart; Linda B Baughn

doi:10.1016/j.clml.2019.06.006

Whole Genome Mate-pair Sequencing of Plasma Cell Neoplasm as a Novel Diagnostic Strategy: A Case of Unrecognized t(2;11) Structural Variation

Clin Lymphoma Myeloma Leuk. 2019 Sep;19(9):598-602. doi: 10.1016/j.clml.2019.06.006. Epub 2019 Jun 18.

Affiliations

¹ Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
² Center for Individualized Medicine-Biomarker Discovery, Mayo Clinic, Scottsdale, AZ.
³ Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ.
⁴ Division of Hematology and Oncology, Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ.
⁵ Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. Electronic address: baughn.linda@mayo.edu.

PMID: 31320253
DOI: 10.1016/j.clml.2019.06.006

No abstract available

Keywords: Atypical CCND1 rearrangement; Fluorescence in situ hybridization (FISH); IGK/CCND1 rearrangement; Next generation sequencing (NGS); Plasma cell myeloma.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Biopsy
Bone Marrow / pathology
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 2*
Female
Gene Rearrangement
Genetic Association Studies
Genetic Predisposition to Disease
Humans
In Situ Hybridization, Fluorescence
Middle Aged
Neoplasms, Plasma Cell / diagnosis*
Neoplasms, Plasma Cell / genetics*
Translocation, Genetic*
Whole Genome Sequencing*