Characterization of lung adenocarcinoma with a cribriform component reveals its association with spread through air spaces and poor outcomes

Qifeng Ding; Donglai Chen; Xiaofan Wang; Junmiao Wen; Chang Chen; Yongsheng Zhang; Zhonghua Xu; Yongbing Chen

doi:10.1016/j.lungcan.2019.06.027

Characterization of lung adenocarcinoma with a cribriform component reveals its association with spread through air spaces and poor outcomes

Lung Cancer. 2019 Aug:134:238-244. doi: 10.1016/j.lungcan.2019.06.027. Epub 2019 Jun 27.

Authors

Qifeng Ding¹, Donglai Chen², Xiaofan Wang¹, Junmiao Wen³, Chang Chen², Yongsheng Zhang⁴, Zhonghua Xu¹, Yongbing Chen⁵

Affiliations

¹ Department of Thoracic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
² Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China.
³ Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
⁴ Department of Pathology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
⁵ Department of Thoracic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China. Electronic address: chentongt@sina.com.

PMID: 31319987
DOI: 10.1016/j.lungcan.2019.06.027

Abstract

Objective: To further investigate the relationship between the cribriform component and spread through air spaces (STAS), and to unravel the potential pathological mechanism of poor prognoses in lung adenocarcinoma (LUAD) patients with a cribriform component.

Methods: We retrospectively reviewed the clinicopathological characteristics of 208 LUADs. The cribriform component was identified by hematoxylin and eosin staining. The identification of STAS referred to our previous study. The relationship between the cribriform component and STAS was determined by using a logistic regression model. The effects of the cribriform component and STAS on prognosis were analyzed using a Cox proportional hazards regression model.

Results: LUAD patients with a cribriform component had significantly inferior outcomes and increased risk of both locoregional and distant recurrences when compared with those with no cribriform component (p < 0.001). Among 67 patients with a cribriform component presented, 48 (71.6%) cases had STAS. The logistic regression model identified that the cribriform component was an independent risk factor for the presence of STAS (p = 0.044). Subgroup analysis showed that Crib+ (cribriform component present)/STAS+ (spread through air spaces positive) patients had significantly inferior outcomes when compared with Crib+/STAS- (spread through air spaces negative) patients (p < 0.001). Moreover, the multivariate Cox regression analysis further confirmed that STAS was an independent risk factor for a worsening recurrence-free survival (RFS) (p = 0.001) and overall survival (OS) (p < 0.001) in LUAD patients with a cribriform component.

Conclusions: Our results indicated that STAS was more frequently observed in LUAD patients with a cribriform component. Moreover, STAS could provide helpful prognostic information in patients with stage I-III LUAD with a cribriform component.

Keywords: Cribriform component; Lung adenocarcinoma; Prognosis; Spread through air spaces.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / mortality*
Adenocarcinoma / pathology*
Aged
Aged, 80 and over
Female
Humans
Immunohistochemistry
Lung Neoplasms / mortality*
Lung Neoplasms / pathology*
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Prognosis
Proportional Hazards Models