Plasmacytoid dendritic cell dysfunction caused by heat stress is improved by administration of Lactococcus lactis strain plasma in mice

Tetsu Sugimura; Kenta Jounai; Konomi Ohshio; Daisuke Fujiwara

doi:10.1080/09168451.2019.1642098

Plasmacytoid dendritic cell dysfunction caused by heat stress is improved by administration of Lactococcus lactis strain plasma in mice

Biosci Biotechnol Biochem. 2019 Nov;83(11):2140-2143. doi: 10.1080/09168451.2019.1642098. Epub 2019 Jul 18.

Authors

Tetsu Sugimura¹, Kenta Jounai^{1

2}, Konomi Ohshio¹, Daisuke Fujiwara¹

Affiliations

¹ Central Laboratories for Key Technologies, Kirin Co. Ltd ., Yokohama , Japan.
² Technical Deveropment Center, Koiwai Dairy Products Co Ltd ., Sayama , Japan.

PMID: 31318317
DOI: 10.1080/09168451.2019.1642098

Abstract

Plasmacytoid dendritic cells (pDCs) are crucial in anti-viral immunity, acting as regulators in both adaptive and innate immunity. In this study, brief heat stress caused a decrease in splenic pDC activity in mice. Administration of Lactococcus lactis strain Plasma (LC-Plasma) significantly suppressed the decrease in pDC activity and IFN-α production. Abbreviations: LC-Plasma: Lactococcus lactis strain Plasma; LAB: lactic acid bacteria; pDC: plasmacytoid dendritic cell; IFN: interferons; mDC: myeloid dendritic cells.

Keywords: strain plasma; Plasmacytoid dendritic cells; heat stress; interferons.

MeSH terms

Animals
Dendritic Cells / immunology*
Heat-Shock Response / immunology*
Lactococcus lactis / physiology*
Mice