Non-small cell lung cancer (NSCLC) is the most common pathological type of lung cancer. In recent years, immunotherapy has developed rapidly. Immune checkpoint inhibitors, especially programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors have made a breakthrough in the treatment of NSCLC and changed the treatment pattern for NSCLC. Immunological checkpoint inhibitors targeting PD-1/PD-L1 are beneficial to patients, both in the first-line and second-line treatment of advanced NSCLC, in the adjuvant treatment of locally-advanced NSCLC, and in the neoadjuvant therapy of early NSCLC, which show an important role in the comprehensive treatment of NSCLC. This article reviews the clinical research progress of immunological checkpoint inhibitors targeting PD-1/PD-L1 in NSCLC. .
【中文题目：PD-1/PD-L1抑制剂在非小细胞肺癌中的 临床研究进展】 【中文摘要：非小细胞肺癌（non-small cell lung cancer, NSCLC）是肺癌最常见的病理类型。近年来，免疫治疗迅速发展，免疫检查点抑制剂尤其是程序性死亡因子-1（programmed death-1, PD-1）/程序性死亡因子配体-1（programmed death-ligand 1, PD-L1）抑制剂已在NSCLC的治疗中取得突破性进展，改变了NSCLC治疗的格局。以PD-1/PD-L1为靶点的免疫检查点抑制剂无论在晚期NSCLC的一线和二线治疗，局部晚期NSCLC的辅助治疗，还是早期NSCLC的新辅助治疗中均为患者带来获益，在NSCLC的综合治疗中显示出重要地位。本文针对以PD-1/PD-L1为靶点的免疫检查点抑制剂在NSCLC中的临床研究进展展开综述。 】 【中文关键词：肺肿瘤；肿瘤免疫治疗；PD-1/PD-L1；免疫检查点抑制剂】.
Keywords: Cancer immunotherapy; Immune checkpoint inhibitor; Lung neoplasms; PD-1/PD-L1.