Preconception and Prenatal Factors and Metabolic Risk

Guoying Wang; Tami R. Bartell; Xiaobin Wang

doi:10.1007/978-3-319-47143-3_3

Preconception and Prenatal Factors and Metabolic Risk

Review

In: Handbook of Life Course Health Development [Internet]. Cham (CH): Springer; 2018.

2017 Nov 21.

Authors

Guoying Wang¹, Tami R. Bartell², Xiaobin Wang³

Book Editors

Neal Halfon¹, Christopher B. Forrest², Richard M. Lerner³, Elaine M. Faustman⁴

Affiliations

¹ Department of Population, Family and Reproductive Health, Center on the Early Life Origins of Disease, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
² Stanley Manne Children’s Research Institute, Ann & Robert H Lurie Children’s Hospital of Chicago, Chicago, IL, USA
³ Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA

Book Affiliations

¹ Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
² Applied Clinical Research Center Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
³ Tufts University, Medford, Massachusetts, USA
⁴ Institute for Risk Analysis and Risk Communication, Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, Washington, USA

Excerpt

The prenatal period is a critical developmental stage for obesity and metabolic outcomes. In light of the global obesity and type 2 diabetes (T2DM) epidemic and growing evidence of early life origins of obesity and diabetes, early identification of individuals at high risk and early prevention of obesity and metabolic syndrome are a key to achieve primary prevention and reverse the trends of the obesity and T2DM epidemics. This chapter will discuss the impact of important preconceptional and prenatal factors, including maternal obesity and/or diabetes, gestational weight gain, and maternal micronutrient status, on in utero and lifelong metabolic outcomes and the possible gene–environment interactions and epigenetic mechanisms underlying early life origins of metabolic risk. Finally, it will provide perspectives on current knowledge gaps and recommendations to advance the field.

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Review