Blood Pressure and the Risk of Acute Kidney Injury in the ICU: Case-Control Versus Case-Crossover Designs

Li-wei H. Lehman; Mengling Feng; Yijun Yang; Roger G. Mark

doi:10.1007/978-3-319-43742-2_25

Blood Pressure and the Risk of Acute Kidney Injury in the ICU: Case-Control Versus Case-Crossover Designs

Review

In: Secondary Analysis of Electronic Health Records [Internet]. Cham (CH): Springer; 2016. Chapter 25.

2016 Sep 10.

Authors

Li-wei H. Lehman¹, Mengling Feng¹, Yijun Yang¹, Roger G. Mark¹

Affiliation

¹ Massachusetts Institute of Technology, Cambridge, MA, USA

Excerpt

This chapter describes two different approaches—a case-control and a case-crossover design—to examine the effect of transient exposure of hypotension on the risk of acute kidney injury (AKI) in intensive care unit (ICU) patients. We highlight the key differences and the design rationale of these two approaches, and present preliminary findings from applying these techniques to study the relationship between hypotension and AKI using the MIMIC II database.

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