The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population. This report provides evidence supporting the hypothesis that Western Diet-fed, aortic-banded Ossabaw swine display an integrated physiological, morphological, and genetic phenotype evocative of cardio-metabolic heart failure. This new preclinical animal model displays a distinctive constellation of findings that are conceivably useful to extending the understanding of how pre-existing cardio-metabolic syndrome can contribute to developing HF.
Keywords: AB, aortic-banded; CON, control; EDPVR, end-diastolic pressure−volume relationship; EF, ejection fraction; HF, heart failure; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; IL1RL1, interleukin 1 receptor-like 1; LV, left ventricle; NF, nuclear factor; PTX3, pentraxin-3; WD, Western Diet; cardio-metabolic disease; heart failure; integrative pathophysiology; preclinical model of cardiovascular disease.