The effect of white kidney bean fertilized with nano-zinc on nutritional and biochemical aspects in rats

Eman E Shaban; Hagar F H Elbakry; Khadiga S Ibrahim; Eman M El Sayed; Dina M Salama; Abdel-Razik H Farrag

doi:10.1016/j.btre.2019.e00357

The effect of white kidney bean fertilized with nano-zinc on nutritional and biochemical aspects in rats

Biotechnol Rep (Amst). 2019 Jun 27:23:e00357. doi: 10.1016/j.btre.2019.e00357. eCollection 2019 Sep.

Authors

Eman E Shaban¹, Hagar F H Elbakry², Khadiga S Ibrahim¹, Eman M El Sayed², Dina M Salama³, Abdel-Razik H Farrag⁴

Affiliations

¹ Environmental & Occupational Medicine Department, National Research Centre, P.O. 12622, Giza, Egypt.
² Nutrition & Food Sciences Department, National Research Centre, P.O. 12622, Giza, Egypt.
³ Vegetable Research Department, National Research Centre, P.O. 12622, Giza, Egypt.
⁴ Pathology Department, National Research Centre, P.O. 12622, Giza, Egypt.

Abstract

This study aims to estimate the safety of white kidney bean (WKB) fertilized by zinc oxide nanoparticles (ZnO-NPs) via studying changes of liver and kidney function, lipid profile and histological examination for the liver and kidney tissue in rats fed on it. Twenty Four male albino rats were used in this study divided into four groups; the first fed balanced diet (control group), the second fed WKB treated with normal ZnO (nWKB), the third fed WKB treated with 20 ppm ZnO-NPs (tWKB-1), and the fourth fed WKB treated with 40 ppm ZnO-NPs (tWKB-2). The results revealed that WKB treated with ZnO-NPs reduced body weight, food efficiency ratio, relative liver weight, and relative spleen weight were increased as well as the most biochemical parameters exhibited non-significant changes as compared to control group. Meanwhile, tWKB-2 group demonstrated a decrease in alkaline phosphatase and aspartate transaminase activities as compared to nWKB group.

Keywords: ALP, alkaline phosphatase; ALT, Alanine transaminase; AST, Aspartate transaminase; HDL-ch, high density lipoprotein cholesterol; Kidney function; LDL, low density lipoprotein; LDL-ch, low density lipoprotein cholesterol; Lipids; Liver function; NPs, nanoparticles; WKB, white kidney bean; White kidney bean; Zinc oxide nanoparticles; ZnO-NPs, zinc oxide nanoparticles; nWKB, Normal white kidney bean; tWKB-1, treated WKB with 20ppm ZnO-NPs; tWKB-2, treated WKB with 40ppm ZnO-NPs.