Abstract
We report a 3-year-old child who was hospitalized because of severe manifestations of the central nervous system. The child died after 6 days of hospitalization. Analysis of postmortem cerebrospinal fluid showed the presence of yellow fever virus RNA. Nucleotide sequencing confirmed that the virus was wild-type yellow fever virus.
Keywords:
CNS; CSF; Yellow fever virus; central nervous system; cerebrospinal fluid; child; flavivirus; meningitis/encephalitis; mosquito-borne infections; vector-borne infections; viruses; wild-type virus; yellow fever; yellow fever virus RNA.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / pharmacology
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Antiviral Agents / therapeutic use
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Autopsy
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Biomarkers
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Brazil
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Child, Preschool
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Disease Progression
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Fatal Outcome
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Female
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Humans
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Phylogeny
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RNA, Viral / genetics*
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Sequence Analysis, DNA
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Symptom Assessment
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Tomography, X-Ray Computed
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Yellow Fever / cerebrospinal fluid*
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Yellow Fever / diagnosis
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Yellow Fever / drug therapy
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Yellow Fever / virology*
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Yellow fever virus / classification
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Yellow fever virus / genetics*
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Yellow fever virus / isolation & purification
Substances
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Antiviral Agents
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Biomarkers
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RNA, Viral