Abstract
The gene mcr-1 conferring resistance to last-line antibiotic colistin has been reported globally. Here, we describe the first detection of plasmid-mediated colistin resistance in Russian wildlife, an isolate of Escherichia coli sequence type 2280 from a black kite (Milvus migrans) scavenging raptor. Whole-genome sequencing and plasmid transferability experiments revealed that mcr-1.1 was located on conjugative IncI2 plasmid pDR164 (59891 bp). Migratory black kites may contribute to the global spread of mobile colistin resistance.
Keywords:
DNA sequencing; Escherichia coli; colistin; kite; landfill; plasmid; wildlife.
Copyright © 2019 American Society for Microbiology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animal Migration
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Animals
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology
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Colistin / metabolism
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Colistin / pharmacology
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Drug Resistance, Bacterial / genetics*
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Escherichia coli / drug effects
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Escherichia coli / enzymology
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Escherichia coli / genetics*
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Escherichia coli / isolation & purification
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Escherichia coli Infections / epidemiology
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Escherichia coli Infections / microbiology
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Escherichia coli Infections / transmission
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Escherichia coli Infections / veterinary*
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Escherichia coli Proteins / genetics*
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Microbial Sensitivity Tests
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Plasmids / chemistry
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Plasmids / metabolism
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Raptors / microbiology*
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Russia / epidemiology
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Whole Genome Sequencing
Substances
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Anti-Bacterial Agents
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Escherichia coli Proteins
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MCR-1 protein, E coli
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Colistin