Plasmid-Mediated mcr-1 Colistin Resistance in Escherichia coli from a Black Kite in Russia

Antimicrob Agents Chemother. 2019 Aug 23;63(9):e01266-19. doi: 10.1128/AAC.01266-19. Print 2019 Sep.

Abstract

The gene mcr-1 conferring resistance to last-line antibiotic colistin has been reported globally. Here, we describe the first detection of plasmid-mediated colistin resistance in Russian wildlife, an isolate of Escherichia coli sequence type 2280 from a black kite (Milvus migrans) scavenging raptor. Whole-genome sequencing and plasmid transferability experiments revealed that mcr-1.1 was located on conjugative IncI2 plasmid pDR164 (59891 bp). Migratory black kites may contribute to the global spread of mobile colistin resistance.

Keywords: DNA sequencing; Escherichia coli; colistin; kite; landfill; plasmid; wildlife.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Migration
  • Animals
  • Anti-Bacterial Agents / metabolism
  • Anti-Bacterial Agents / pharmacology
  • Colistin / metabolism
  • Colistin / pharmacology
  • Drug Resistance, Bacterial / genetics*
  • Escherichia coli / drug effects
  • Escherichia coli / enzymology
  • Escherichia coli / genetics*
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / epidemiology
  • Escherichia coli Infections / microbiology
  • Escherichia coli Infections / transmission
  • Escherichia coli Infections / veterinary*
  • Escherichia coli Proteins / genetics*
  • Microbial Sensitivity Tests
  • Plasmids / chemistry
  • Plasmids / metabolism
  • Raptors / microbiology*
  • Russia / epidemiology
  • Whole Genome Sequencing

Substances

  • Anti-Bacterial Agents
  • Escherichia coli Proteins
  • MCR-1 protein, E coli
  • Colistin