Current trends in diffusion NMR and MRI methods development are reviewed. While great efforts are still directed towards further improving the spectral, spatial, and relaxation rate resolution of basic diffusion measurements, recent improvements in magnetic field gradient technology on whole-body scanners have enabled an exciting line of research involving MRI implementations of advanced diffusion NMR methods with motion-encoding gradient waveforms designed for multidimensional separation and correlation of properties like short-time diffusivity, restriction, anisotropy, flow, and exchange, thereby opening up for highly specific characterization of microstructure and heterogeneity in healthy and diseased tissues in a clinical setting.
Keywords: Anisotropy; Diffusion; Exchange; Flow; Magnetic resonance; Microstructure; Multidimensional; Restriction.
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