Ultra high dose rate Synchrotron Microbeam Radiation Therapy. Preclinical evidence in view of a clinical transfer

Laura Eling; Audrey Bouchet; Christian Nemoz; Valentin Djonov; Jacques Balosso; Jean Laissue; Elke Bräuer-Krisch; Jean Francois Adam; Raphael Serduc

doi:10.1016/j.radonc.2019.06.030

Ultra high dose rate Synchrotron Microbeam Radiation Therapy. Preclinical evidence in view of a clinical transfer

Radiother Oncol. 2019 Oct:139:56-61. doi: 10.1016/j.radonc.2019.06.030. Epub 2019 Jul 12.

Authors

Laura Eling¹, Audrey Bouchet¹, Christian Nemoz², Valentin Djonov³, Jacques Balosso⁴, Jean Laissue⁵, Elke Bräuer-Krisch², Jean Francois Adam¹, Raphael Serduc⁶

Affiliations

¹ Inserm UA7, Synchrotron Radiation for Biomedical Research (STROBE), Université Grenoble Alpes - ID17, Installation Européenne du Rayonnement Synchrotron (ESRF) CS 40220, Grenoble Cedex 9, France.
² ESRF, Grenoble, France.
³ Institute of Anatomy, University of Bern, Switzerland.
⁴ CRLCC Francois Baclesse, 14000 Caen, France.
⁵ University of Bern, Switzerland.
⁶ Inserm UA7, Synchrotron Radiation for Biomedical Research (STROBE), Université Grenoble Alpes - ID17, Installation Européenne du Rayonnement Synchrotron (ESRF) CS 40220, Grenoble Cedex 9, France. Electronic address: serduc@esrf.fr.

PMID: 31307824
DOI: 10.1016/j.radonc.2019.06.030

Abstract

This paper reviews the current state of the art of an emerging form of radiosurgery dedicated to brain tumour treatment and which operates at very high dose rate (kGy·s^-1). Microbeam Radiation Therapy uses synchrotron-generated X-rays which triggered normal tissue sparing partially mediated by FLASH effect.

Keywords: Brain tumours responses; High dose rate; Normal tissue sparing; Synchrotron Microbeam Radiation Therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Brain Neoplasms / blood supply
Brain Neoplasms / radiotherapy*
Clinical Protocols
Disease Models, Animal
Humans
Radiosurgery / methods*
Synchrotrons*
X-Rays