Implications of liquid-liquid phase separation in plant chromatin organization and transcriptional control

Nan Wang; Chang Liu

doi:10.1016/j.gde.2019.06.003

Implications of liquid-liquid phase separation in plant chromatin organization and transcriptional control

Curr Opin Genet Dev. 2019 Apr:55:59-65. doi: 10.1016/j.gde.2019.06.003. Epub 2019 Jul 12.

Authors

Nan Wang¹, Chang Liu²

Affiliations

¹ Center for Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany.
² Center for Plant Molecular Biology (ZMBP), University of Tübingen, Auf der Morgenstelle 32, 72076 Tübingen, Germany. Electronic address: chang.liu@zmbp.uni-tuebingen.de.

PMID: 31306885
DOI: 10.1016/j.gde.2019.06.003

Abstract

As an essential feature of three-dimensional (3D) genome organization, compartmentalization of chromatin in the nucleus is tightly linked to various chromatin activities. Recent work on liquid-liquid phase separation (LLPS), which drives the formation of miscellaneous membrane-less compartments in cells, suggests that it is a critical aspect of chromatin compartmentalization. In this review, we provide an overview of recent work in the animal field that focuses on understanding how LLPS is involved in 3D chromatin organization and transcriptional regulation. By combining scattered information in 3D plant genomics, we attempt to interpret some known plant chromatin organization patterns in the context of LLPS. Moreover, we discuss and speculate factors that can undergo phase separation to modulate chromatin structure and gene expression in plants.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Nucleus
Chromatin / chemistry*
Chromatin / genetics*
Gene Expression Regulation, Plant*
Genome, Plant*
Liquid-Liquid Extraction / methods*
Plants / genetics*
Transcription, Genetic*

Substances

Chromatin