Association between PDE4D polymorphism and ischemic stroke in young population

Xuejing Yue; Liu Lixia; Haiqing Yan; Ping Zhang; Yongkun Gui; Jinggui Song

doi:10.1016/j.sjbs.2019.04.007

Association between PDE4D polymorphism and ischemic stroke in young population

Saudi J Biol Sci. 2019 Jul;26(5):1023-1026. doi: 10.1016/j.sjbs.2019.04.007. Epub 2019 Apr 9.

Authors

Xuejing Yue¹, Liu Lixia¹, Haiqing Yan², Ping Zhang², Yongkun Gui², Jinggui Song²

Affiliations

¹ School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453000, China.
² The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China.

Abstract

Objective: To explore the association between the polymorphisms of the phosphodiesterase (PDE) 4D gene (SNP83 and SNP87) and the risk of ischemic stroke (IS) in Chinese young population.

Methods: This study included 393 patients who were divided into IS group and non-IS group. Semiconductor high-throughput sequencing technology and multivariate logistic regression analysis were performed.

Results: In the case group, the frequency of CC genotype and C allele of the SNP83 gene was significantly higher than that in the control group. There was no significant difference in genotype frequency distribution of SNP87 between the two groups.

Conclusion: We found an association between SNP83 and the risk of IS in Chinese young population from northern Henan province. There was not a significant association between SNP87 and IS in Chinese young population.

Keywords: Gene polymorphism; Ischemic stroke; Phosphodiesterase 4D.