Pediatric pituitary adenomas

Childs Nerv Syst. 2019 Nov;35(11):2107-2118. doi: 10.1007/s00381-019-04293-y. Epub 2019 Jul 13.

Abstract

Background: Pediatric pituitary adenomas are a rare medical entity that makes up a small portion of intracranial tumors in children and adolescents. Although benign, the majority of these lesions are secreting functional tumors with the potential for physiological sequela that can profoundly affect a child's development.

Focus of review: In this review, we discuss the medical and surgical management of these tumors with a focus on clinical presentation, diagnostic identification, surgical approach, and associated adjuvant therapies. We will also discuss our current treatment paradigm using endoscopic, open, and combined approaches to treat these tumors. The management of pituitary tumors requires a multidisciplinary team of surgeons, endocrinologists, and neuroanesthesiologists as well as neurocritical care specialists to deliver comprehensive care.

Keywords: Endonasal; Pediatric; Pituitary adenoma; Skull base.

Publication types

  • Review

MeSH terms

  • ACTH-Secreting Pituitary Adenoma / diagnostic imaging
  • ACTH-Secreting Pituitary Adenoma / metabolism
  • ACTH-Secreting Pituitary Adenoma / physiopathology
  • ACTH-Secreting Pituitary Adenoma / surgery*
  • Adenoma / diagnostic imaging
  • Adenoma / metabolism
  • Adenoma / physiopathology
  • Adenoma / surgery
  • Adolescent
  • Child
  • Child, Preschool
  • Craniotomy
  • Dopamine Agonists / therapeutic use
  • Growth Hormone-Secreting Pituitary Adenoma / diagnostic imaging
  • Growth Hormone-Secreting Pituitary Adenoma / metabolism
  • Growth Hormone-Secreting Pituitary Adenoma / physiopathology
  • Growth Hormone-Secreting Pituitary Adenoma / surgery*
  • Humans
  • Microsurgery / methods*
  • Nasal Cavity
  • Natural Orifice Endoscopic Surgery / methods
  • Neuroendoscopy / methods*
  • Pituitary Neoplasms / diagnostic imaging
  • Pituitary Neoplasms / metabolism
  • Pituitary Neoplasms / physiopathology
  • Pituitary Neoplasms / therapy*
  • Prolactinoma / diagnostic imaging
  • Prolactinoma / physiopathology
  • Prolactinoma / therapy*
  • Sphenoid Bone

Substances

  • Dopamine Agonists