Elastin architecture

Howard Vindin; Suzanne M Mithieux; Anthony S Weiss

doi:10.1016/j.matbio.2019.07.005

Elastin architecture

Matrix Biol. 2019 Nov:84:4-16. doi: 10.1016/j.matbio.2019.07.005. Epub 2019 Jul 10.

Authors

Howard Vindin¹, Suzanne M Mithieux¹, Anthony S Weiss²

Affiliations

¹ Charles Perkins Centre, The University of Sydney, 2006 Sydney, NSW, Australia; School of Life and Environmental Sciences, The University of Sydney, 2006 Sydney, NSW, Australia.
² Charles Perkins Centre, The University of Sydney, 2006 Sydney, NSW, Australia; School of Life and Environmental Sciences, The University of Sydney, 2006 Sydney, NSW, Australia; Bosch Institute, The University of Sydney, 2006 Sydney, NSW, Australia; Sydney Nano Institute, The University of Sydney, 2006 Sydney, NSW, Australia. Electronic address: tony.weiss@sydney.edu.au.

PMID: 31301399
DOI: 10.1016/j.matbio.2019.07.005

Abstract

Elastic fibers are an essential component of the extracellular matrix where they provide structural integrity and elastic recoil in a number of important tissues. A major constituent of these fibers is elastin, an insoluble metabolically stable polymer formed via extensive crosslinking of the monomeric precursor tropoelastin. Research over the past few decades has shown that tropoelastin possesses unique structural features that differ from both intrinsically disordered and globular proteins. This review details the advances in our understanding of tropoelastin's structural properties and illustrates how these dictate its biological function.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Elastin / chemistry*
Elastin / metabolism*
Extracellular Matrix / chemistry
Extracellular Matrix / metabolism*
Humans
Protein Domains
Tropoelastin / chemistry
Tropoelastin / metabolism

Substances

Tropoelastin
Elastin