Graded Dalbavancin Challenge in a Patient With Severe Vancomycin Hypersensitivity Reaction

Kelly T Ishizuka; Thao K Tran; Andrew G Ayars; Alice S Chau; Jeannie D Chan

doi:10.1093/cid/ciz646

Graded Dalbavancin Challenge in a Patient With Severe Vancomycin Hypersensitivity Reaction

Clin Infect Dis. 2020 Mar 3;70(6):1230-1232. doi: 10.1093/cid/ciz646.

Authors

Kelly T Ishizuka^{1

2}, Thao K Tran^{1

2}, Andrew G Ayars³, Alice S Chau³, Jeannie D Chan^{1

2

3}

Affiliations

¹ Department of Pharmacy, Harborview Medical Center, University of Washington, Seattle.
² School of Pharmacy, University of Washington, Seattle.
³ Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle.

PMID: 31300814
DOI: 10.1093/cid/ciz646

Abstract

Cross-reactivity should be considered when treating patients with a previous hypersensitivity reaction within the same class of antibiotics that share similar chemical structures. This case report describes a patient with severe hypersensitivity reaction to vancomycin who successfully tolerated a dalbavancin graded challenge.

Publication types

Case Reports

MeSH terms

Anti-Bacterial Agents / adverse effects
Humans
Microbial Sensitivity Tests
Teicoplanin* / adverse effects
Teicoplanin* / analogs & derivatives
Vancomycin* / adverse effects

Substances

Anti-Bacterial Agents
Teicoplanin
Vancomycin
dalbavancin