Central Giant Cell Granuloma Treated with Intralesional Corticosteroid Injections and Bisphosphonates: A Long-Term Follow-Up Case Study

Head Neck Pathol. 2020 Jun;14(2):497-502. doi: 10.1007/s12105-019-01053-x. Epub 2019 Jul 11.

Abstract

Central giant cell granuloma (CGCG) is a benign intraosseous lesion of the head and neck with potential for aggressive and locally destructive behaviour. Lesions of the maxilla tend to expand more than those of the mandible due to the thinner cortices and spongy tissue of this location. Surgical removal is the most common treatment; however, it may be disfiguring in aggressive cases, especially for lesions located in the maxilla. Alternative treatments, such as intralesional corticosteroid injections, have been performed with satisfactory results. We report a case of a 12-year-old female patient with a CGCG of the left maxilla that was treated with 40 doses of intralesional triamcinolone acetonide infiltrations combined with alendronate sodium and calcium carbonate. Clinical and imaging follow-up over 12 years demonstrates improvement in the patient's condition.

Keywords: Corticosteroid; Giant cell; Granuloma; Injections; Intralesional; Triamcinolone acetonide.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage*
  • Alendronate / administration & dosage
  • Anti-Inflammatory Agents / administration & dosage
  • Bone Density Conservation Agents / administration & dosage
  • Calcium Carbonate / administration & dosage
  • Child
  • Diphosphonates / administration & dosage*
  • Female
  • Follow-Up Studies
  • Granuloma, Giant Cell / drug therapy*
  • Granuloma, Giant Cell / pathology*
  • Humans
  • Injections, Intralesional
  • Maxillary Diseases / drug therapy*
  • Maxillary Diseases / pathology*
  • Time
  • Triamcinolone Acetonide / administration & dosage

Substances

  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents
  • Bone Density Conservation Agents
  • Diphosphonates
  • Triamcinolone Acetonide
  • Calcium Carbonate
  • Alendronate