Dataset on structure, stability and myocardial effects of a new hybrid aspirin containing nitrogen monoxide-releasing molsidomine moiety

Kitti Szőke; Attila Czompa; István Lekli; Péter Szabados-Fürjesi; Mihály Herczeg; Magdolna Csávás; Anikó Borbás; Pál Herczegh; Árpád Tósaki

doi:10.1016/j.dib.2019.104146

Dataset on structure, stability and myocardial effects of a new hybrid aspirin containing nitrogen monoxide-releasing molsidomine moiety

Data Brief. 2019 Jun 12:25:104146. doi: 10.1016/j.dib.2019.104146. eCollection 2019 Aug.

Authors

Kitti Szőke¹, Attila Czompa¹, István Lekli¹, Péter Szabados-Fürjesi^{1

2}, Mihály Herczeg³, Magdolna Csávás³, Anikó Borbás³, Pál Herczegh³, Árpád Tósaki¹

Affiliations

¹ Department of Pharmacology, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary.
² Department of Bioanalytical Chemistry, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary.
³ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary.

Abstract

Herein ¹H and ¹³C NMR spectra of ERJ-500, a new hybrid aspirin derivative, covalently conjugated to nitrogen monoxide donor linsidomine are presented as well as NMR spectra of its synthetic intermediate compounds. HPLC-MS measurements data are also included, demonstrating the stability of the linsidomine-aspirin hybrid in oxidation reactions. This data article also concerns miscellaneous myocardial parameters of isolated rat hearts as a complementation of the tables shown in the paper entitled "A new, vasoactive hybrid aspirin containing nitrogen monoxide-releasing molsidomine moiety" Szoke et al., 2019. Column tables represent data of aorta flow, aortic pressure, derivated aortic pressure and cardiac output.

Keywords: ERJ-500; Hybrid aspirin; Molsidomine.