Update of therapeutic planning tables oriented towards obtaining therapeutic objectives
Clin Investig Arterioscler. 2019 Nov-Dec;31(6):271-277.
doi: 10.1016/j.arteri.2019.04.005.
Epub 2019 Jul 9.
[Article in
English,
Spanish]
Affiliations
- 1 Unidad de Medicina Vascular y Metabolismo, Hospital Universitario Sant Joan, Universitat Rovira i Virgili, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Tarragona, España. Electronic address: luis.masana@urv.cat.
- 2 Unidad de Medicina Vascular y Metabolismo, Hospital Universitario Sant Joan, Universitat Rovira i Virgili, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Tarragona, España.
Abstract
This is the fourth update of the therapeutic planning tables. These tables are a simple desktop tool, to help in determining the most appropriate oral cholesterol-lowering therapy for patient. This can either be with monotherapy or combination therapy (statins plus ezetimibe), taking into account the patient LDL cholesterol (LDL-C) and the therapeutic objective to be achieved. These therapeutic indications are based on 2 fundamental principles: the causality of LDL-C, and that the effect of cardiovascular protection depends on the decrease in LDL-C. It is based on a colour code that indicates the drugs that have the necessary power to meet the therapeutic objectives of the patient. We provide some recommendations on the strategy to follow to implement the most effective treatment. It is assessed up to what levels a decrease in LDL-C can be expected by adding a PCSK9 inhibitor.
Keywords:
Cholesterol; Colesterol; LDL; Lipid-lowering treatment; Objetivos terapéuticos; Therapeutic objectives; Tratamiento hipolipidemiante.
Copyright © 2019 Sociedad Española de Arteriosclerosis. Publicado por Elsevier España, S.L.U. All rights reserved.
MeSH terms
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Anticholesteremic Agents / therapeutic use*
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Cardiovascular Diseases / prevention & control*
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Cholesterol, LDL / blood*
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Dyslipidemias / blood
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Dyslipidemias / drug therapy*
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
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Mendelian Randomization Analysis
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Meta-Analysis as Topic
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PCSK9 Inhibitors*
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Practice Guidelines as Topic
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Randomized Controlled Trials as Topic
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Reference Values
Substances
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Anticholesteremic Agents
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Cholesterol, LDL
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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PCSK9 Inhibitors
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PCSK9 protein, human