Avian Stress-Related Transcriptome and Selenotranscriptome: Role during Exposure to Heavy Metals and Heat Stress

Isidoros Seremelis; Georgios P Danezis; Athanasios C Pappas; Evangelos Zoidis; Kostas Fegeros

doi:10.3390/antiox8070216

Avian Stress-Related Transcriptome and Selenotranscriptome: Role during Exposure to Heavy Metals and Heat Stress

Antioxidants (Basel). 2019 Jul 10;8(7):216. doi: 10.3390/antiox8070216.

Authors

Isidoros Seremelis¹, Georgios P Danezis¹, Athanasios C Pappas², Evangelos Zoidis³, Kostas Fegeros²

Affiliations

¹ Chemistry Laboratory, Department of Food Science and Human Nutrition, Agricultural University of Athens, 75 Iera Odos, 11855 Athens, Greece.
² Department of Nutritional Physiology and Feeding, Faculty of Animal Science, Agricultural University of Athens, 75 Iera Odos, 11855 Athens, Greece.
³ Department of Nutritional Physiology and Feeding, Faculty of Animal Science, Agricultural University of Athens, 75 Iera Odos, 11855 Athens, Greece. ezoidis@aua.gr.

Abstract

Selenium, through incorporation into selenoproteins, is one of the key elements of the antioxidant system. Over the past few years there has been increased interest in exploring those molecular mechanisms in chicken, responsible for the development of this protection system. In more detail, Cd/Pb poisoning and heat stress increase oxidation, mRNA levels of inflammatory proteins, and apoptotic proteins. Selenium seems to enhance the antioxidant status and alleviates these effects via upregulation of antioxidant proteins and other molecular effects. In this review, we analyze avian transcriptome key elements with particular emphasis on interactions with heavy metals and on relation to heat stress.

Keywords: Animal health; heat stress; heavy metals; selenium; selenoprotein; selenotranscriptome.

Publication types

Review