Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications

J Control Release. 2019 Sep 10:309:302-332. doi: 10.1016/j.jconrel.2019.07.003. Epub 2019 Jul 8.

Abstract

An increased interest in Pickering emulsions has emerged over the last 15 years, mainly related to their very attractive properties compared to regular emulsions, namely their excellent stability and their numerous possible applications. In this review, after detailing the interest of Pickering emulsions, their main preparation processes are presented and their advantages and disadvantages discussed. In the third part, the key parameters that govern Pickering emulsions type, droplet size and stability are analyzed. Finally, the interest and the potential of Pickering emulsions for pharmaceutical applications are exposed and discussed, taking all the administration routes into consideration and focusing on organic particles.

Keywords: Organic particles; Pharmaceutical applications; Pickering emulsion; Preparation processes; Tuning parameters.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chemistry, Pharmaceutical / instrumentation
  • Chemistry, Pharmaceutical / methods*
  • Cyclodextrins / chemistry
  • Drug Compounding / instrumentation
  • Drug Compounding / methods
  • Drug Delivery Systems / instrumentation
  • Drug Delivery Systems / methods
  • Emulsions / chemistry*
  • Equipment Design
  • Fats / chemistry
  • Humans
  • Particle Size
  • Pharmaceutical Preparations / administration & dosage
  • Polymers / chemistry
  • Polysaccharides / chemistry
  • Proteins / chemistry
  • Surface-Active Agents / chemistry*

Substances

  • Cyclodextrins
  • Emulsions
  • Fats
  • Pharmaceutical Preparations
  • Polymers
  • Polysaccharides
  • Proteins
  • Surface-Active Agents