A synthesis efficiency algorithm, which must be based on concrete and reliable criteria, is essential for the evaluation and control of complex chemical synthesis, notably multicomponent reactions (MCRs). An algorithm has been developed to precisely evaluate even highly complex syntheses with regards to their synthesis efficiency Eff syn as a tool for strict compliance with green chemistry requirements, and for economic progress. The mathematical operations are highly suitable for electronic data processing (EDP). This algorithm is also suitable as a basis for fair cost assessment of complex chemical syntheses.
Keywords: efficiency; efficiency algorithm; multicomponent; overall yield; synthesis algorithm; synthesis efficiency; synthesis evaluation.