Unresectable recurrence malignant sacrococcygeal teratoma in children treated with chemoradiotherapy: Case report and literature review

Yecai Huang; Mei Feng; Jun Yin; Bingyu Fu; Jinyi Lang

doi:10.1016/j.rpor.2019.06.002

Unresectable recurrence malignant sacrococcygeal teratoma in children treated with chemoradiotherapy: Case report and literature review

Rep Pract Oncol Radiother. 2019 Jul-Aug;24(4):392-398. doi: 10.1016/j.rpor.2019.06.002. Epub 2019 Jun 22.

Authors

Yecai Huang¹, Mei Feng¹, Jun Yin¹, Bingyu Fu¹, Jinyi Lang¹

Affiliation

¹ Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Abstract

Sacrococcygeal teratoma is the most common germ cell neoplasia that consists of tissues derived from primitive germ layers. Approximately 10-20% of patients are malignant. Because of the high rate of recurrence, treatment strategies for malignant sacrococcygeal teratomas are limited. Hence, we report a case of malignant sacrococcygeal teratoma treated with concurrent chemoradiotherapy plus adjuvant chemotherapy and review the literature. This case report indicates that chemoradiation plus adjuvant chemotherapy may be a treatment option for malignant SCT which is not technically resectable or with residual lesion after surgery.

Keywords: AFP, α-fetoprotein; Chemotherapy; MRI, magnetic resonance imaging; Malignant sacrococcygeal teratoma; PEB, etoposide (VP-16), cisplatin (DDP) and bleomycin (BLM); Radiotherapy; SCT, sacrococcygeal teratoma; VMAT, volume-modulated arc therapy; hCG, human chorionic gonadotropin.

Publication types

Case Reports