A NIR light-triggered drug delivery system using core-shell gold nanostars-mesoporous silica nanoparticles based on multiphoton absorption photo-dissociation of 2-nitrobenzyl PEG

Chem Commun (Camb). 2019 Aug 7;55(61):9039-9042. doi: 10.1039/c9cc04260a. Epub 2019 Jul 11.

Abstract

Gold nanostars coated with a mesoporous silica shell and functionalized with poly(ethylene glycol) containing photolabile 2-nitrobenzyl moieties are able to release doxorubicin after NIR light irradiation at low power irradiance via a multiphoton absorption photo-dissociation process.

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Doxorubicin / pharmacology
  • Drug Carriers / chemical synthesis
  • Drug Carriers / chemistry*
  • Drug Carriers / toxicity
  • Drug Liberation
  • Gold / chemistry*
  • HeLa Cells
  • Humans
  • Infrared Rays
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / radiation effects
  • Metal Nanoparticles / toxicity
  • Nitrobenzenes / chemical synthesis
  • Nitrobenzenes / chemistry*
  • Nitrobenzenes / radiation effects
  • Nitrobenzenes / toxicity
  • Polyethylene Glycols / chemical synthesis
  • Polyethylene Glycols / chemistry*
  • Polyethylene Glycols / toxicity
  • Porosity
  • Silicon Dioxide / chemistry*

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Nitrobenzenes
  • Polyethylene Glycols
  • Gold
  • Silicon Dioxide
  • Doxorubicin