Coherence transfer delay optimisation in PSYCOSY experiments

Alan M Kenwright; Juan A Aguilar; Banabithi Koley Seth; Ilya Kuprov

doi:10.1002/mrc.4920

Coherence transfer delay optimisation in PSYCOSY experiments

Magn Reson Chem. 2020 Jan;58(1):51-55. doi: 10.1002/mrc.4920. Epub 2019 Jul 22.

Authors

Alan M Kenwright¹, Juan A Aguilar¹, Banabithi Koley Seth¹, Ilya Kuprov²

Affiliations

¹ Department of Chemistry, University of Durham, Durham, UK.
² Department of Chemistry, University of Southampton, Southampton, UK.

PMID: 31291477
DOI: 10.1002/mrc.4920

Abstract

PSYCOSY is an f1 broadband homonuclear decoupled version of the COSY nuclear magnetic resonance pulse sequence. Here, we investigate by a combination of experimental measurements, spatially distributed spin dynamics simulations, and analytical predictions the coherence evolution delay necessary in PSYCOSY experiments to ensure intensity discrimination in favour of the correlations typically arising from short range (ⁿ J, n ≤ 3) ¹ H-¹ H couplings and show that, in general, a coherence evolution delay of around 35 ms is optimum.

Keywords: 1H; NMR; numerical simulation; pure shift COSY.

Publication types

Research Support, Non-U.S. Gov't

Abstract

Publication types

Grants and funding