Red light-promoted skin barrier recovery: Spatiotemporal evaluation by transepidermal potential

Yuina Abe; Hajime Konno; Shotaro Yoshida; Takeshi Yamauchi; Kenshi Yamasaki; Mitsuhiro Denda; Matsuhiko Nishizawa

doi:10.1371/journal.pone.0219198

Red light-promoted skin barrier recovery: Spatiotemporal evaluation by transepidermal potential

PLoS One. 2019 Jul 10;14(7):e0219198. doi: 10.1371/journal.pone.0219198. eCollection 2019.

Authors

Yuina Abe¹, Hajime Konno¹, Shotaro Yoshida¹, Takeshi Yamauchi², Kenshi Yamasaki², Mitsuhiro Denda³, Matsuhiko Nishizawa¹

Affiliations

¹ Department of Finemechanics, Graduate School of Engineering, Tohoku University, Aramaki Aoba, Sendai, Japan.
² Department of Dermatology, Graduate School of Medicine, Tohoku University, Seiryo-machi, Sendai, Japan.
³ Shiseido Research Center, Fukuura, Kanazawa-ku, Yokohama, Japan.

Abstract

The light-promoted recovery of epidermal barrier of skin was evaluated by the associated recovery of transepidermal potential (TEP), the potential difference between the surface and dermis of skin, by using porcine skin samples. An accelerated recovery of TEP was observed by irradiation of red light with the irradiance of 40 mW/cm2 and a duration of > 10 min. The influence of the light stimulation to the surroundings (~ 20 mm) was also observed. The irradiations of blue and purple lights were ineffective in accelerating the barrier recovery. These characteristics of the light stimulation would be useful for the design of effective and safe phototherapy devices for skin. The present study proves that the TEP can serve as a spatiotemporal indicator of the epidermal barrier function.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetone / metabolism
Animals
Dermis / radiation effects*
Epidermis / radiation effects*
Humans
Light
Phototherapy*
Salts / metabolism
Skin / radiation effects*
Surface Properties / radiation effects
Swine

Substances

Salts
Acetone

Grants and funding

This work was supported by Tohoku University Institute for Promoting Graduate Degree Programs Division for Interdisciplinary Advanced Research and Education (DIARE), Center of Innovation Program (COI-Stream), MIRAI Project (17944087) of Japan Science and Technology Agency (JST), and financially by Grand-in-Aid for JSPS Research Fellow (17J03919), Scientific Research A (18H04158) and Challenging Exploratory Research (18K19896) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. Shiseido Research Center provided support in the form of salaries for an author MD, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of the author are articulated in the "author contributions" section.