Effects of Lactobacillus plantarum CQPC01-fermented soybean milk on activated carbon-induced constipation through its antioxidant activity in mice

Bihui Liu; Xiao Xiao; Xianrong Zhou; Jie Zhou; Lingxia Lan; Xingyao Long; Yanni Pan; Muying Du; Xin Zhao

doi:10.1002/fsn3.1048

Effects of Lactobacillus plantarum CQPC01-fermented soybean milk on activated carbon-induced constipation through its antioxidant activity in mice

Food Sci Nutr. 2019 May 1;7(6):2068-2082. doi: 10.1002/fsn3.1048. eCollection 2019 Jun.

Authors

Bihui Liu^{1

2

3

4}, Xiao Xiao⁵, Xianrong Zhou^{1

6}, Jie Zhou⁶, Lingxia Lan⁶, Xingyao Long^{1

7}, Yanni Pan^{1

7}, Muying Du⁶, Xin Zhao^{1

2

3}

Affiliations

¹ Chongqing Collaborative Innovation Center for Functional Food Chongqing University of Education Chongqing China.
² Chongqing Engineering Research Center of Functional Food Chongqing University of Education Chongqing China.
³ Chongqing Engineering Laboratory for Research and Development of Functional Food Chongqing University of Education Chongqing China.
⁴ College of Biological and Chemical Engineering Chongqing University of Education Chongqing China.
⁵ Department of Gastroenterology Emergency Medical Center of Chongqing The Affiliated Central Hospital of Chongqing University Chongqing China.
⁶ College of Food Science Southwest University Chongqing China.
⁷ Department of Food Science and Biotechnology Cha University Seongnam Korea.

Abstract

A newly found strain, Lactobacillus plantarum CQPC01 (LP-CQPC01), was used for soybean milk fermentation, and its effects against constipation were determined. LP-CQPC01-FSM (LP-CQPC01-fermented soybean milk) was found to have six kinds of soybean isoflavones; the isoflavones of LP-CQPC01-FSM were more than those of Lactobacillus bulgaricus-fermented soybean milk (LB-FSM) and unfermented soybean milk (U-FSM). Animal experiment showed that the MTL, Gas, ET, AchE, SP, VIP, and GSH levels in the constipated mice were increased; however, the SS, MPO, NO, and MDA levels in the constipated mice were reduced by soybean milk treatment. Further, LP-CQPC01-FSM increased the mRNA and protein expression of Cu/Zn-SOD, Mn-SOD, CAT, c-Kit, SCF, and GDNF and reduced the expression of TRPV1 and NOS relative to those of the mice with untreated constipation. LP-CQPC01 could be used as a new starter to produce high-quality soybean milk, which might be used as a functional drink.

Keywords: Lactobacillus plantarum CQPC01; gene; mice; pickled cabbage; soybean isoflavone.