Chromosome Organization: Making Room in a Crowd

Handuo Shi; Kerwyn Casey Huang

doi:10.1016/j.cub.2019.06.002

Chromosome Organization: Making Room in a Crowd

Curr Biol. 2019 Jul 8;29(13):R630-R632. doi: 10.1016/j.cub.2019.06.002.

Authors

Handuo Shi¹, Kerwyn Casey Huang²

Affiliations

¹ Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
² Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA. Electronic address: kchuang@stanford.edu.

PMID: 31287980
DOI: 10.1016/j.cub.2019.06.002

Abstract

Despite their small size and lack of membrane-based DNA encapsulation, prokaryotic cells still organize and scale their nucleoid in specific subcellular regions. Two studies show that the DNA-free regions in prokaryotes are full of large biomolecules, which exclude DNA via entropic forces.

Publication types

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MeSH terms

Bacteria / genetics*
Chromosomes*
Cytoplasm
Prokaryotic Cells