Abstract
Coordination of ruthenium arene fragments on carbosilane dendrimers' surface greatly increases their antitumor properties. Newly synthetized ruthenium dendrimers are water-soluble, monodisperse and stable. Since carbosilane dendrimers are good carriers of drugs and genes, the presence of ruthenium in their structure makes them promising candidates for new drug delivery systems with improved antitumor potential. Carbosilane ruthenium dendrimers are more toxic to cancer cells than normal cells. Results of several in vitro studies applied here indicate that carbosilane ruthenium dendrimers induce apoptosis in promyelocytic leukemia HL-60 cells.
Keywords:
HL-60 cell line; anticancer drug; apoptosis; carbosilane dendrimer; necroptosis; ruthenium.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Dendrimers / chemical synthesis
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Dendrimers / chemistry
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Dendrimers / pharmacology*
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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HL-60 Cells
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Humans
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Leukemia, Promyelocytic, Acute / drug therapy*
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Leukemia, Promyelocytic, Acute / metabolism
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Leukemia, Promyelocytic, Acute / pathology
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Molecular Structure
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Organometallic Compounds / chemical synthesis
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology*
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Reactive Oxygen Species / analysis
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Reactive Oxygen Species / metabolism
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Ruthenium / chemistry
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Ruthenium / pharmacology*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Dendrimers
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Organometallic Compounds
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Reactive Oxygen Species
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Ruthenium