Anthraquinone-Based Specialized Metabolites from Rhizomes of Bulbine natalensis

J Nat Prod. 2019 Jul 26;82(7):1893-1901. doi: 10.1021/acs.jnatprod.9b00187. Epub 2019 Jul 9.

Abstract

The rhizomes of Bulbine natalensis furnished six previously unreported anthraquinone derivatives (1-6), together with eight known specialized metabolites. Their structures were determined by interpretation of 1D and 2D NMR and HRESIMS data. The absolute configurations of compounds 1-6 were determined by specific rotation and circular dichroism experiments. The isolated compounds were evaluated for antimicrobial activities, and compound 1 was found to be a moderate inhibitor (IC50 0.02 μM) against methicillin-resistant Staphylococcus aureus (MRSA).

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anthraquinones / isolation & purification
  • Anthraquinones / metabolism*
  • Anthraquinones / pharmacology
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Asphodelaceae / metabolism*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Rhizome / metabolism*
  • Spectrum Analysis / methods

Substances

  • Anthraquinones
  • Anti-Bacterial Agents
  • Antifungal Agents