Abstract
A novel New Delhi metallo-β-lactamase (NDM) variant, NDM-19, was identified in a carbapenem-resistant E. coli strain isolated from a subcutaneous infection of a laparotomy scar from an Egyptian patient in a Swiss hospital. NDM-19 is a derivative of NDM-7, from which it differs by a single amino acid substitution (Ala233Val). Under zinc-limiting growth conditions, E. coli DH5α transformants producing NDM-19 displayed reduced susceptibility towards expanded-spectrum cephalosporins and carbapenems as compared to transformants producing NDM-1 or NDM-7.
Copyright © 2019 Elsevier Inc. All rights reserved.
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Carbapenems / pharmacology
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Cephalosporins / pharmacology
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Culture Media / chemistry
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Drug Resistance, Multiple, Bacterial
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Escherichia coli / drug effects
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Escherichia coli / enzymology*
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Escherichia coli / genetics
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Escherichia coli / isolation & purification
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Escherichia coli Infections / microbiology
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / metabolism*
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Humans
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Microbial Sensitivity Tests
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Mutation
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Plasmids / genetics
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Recombinant Proteins / genetics
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Recombinant Proteins / metabolism
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Surgical Wound Infection / microbiology
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Switzerland
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Zinc / analysis
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Zinc / metabolism*
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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Anti-Bacterial Agents
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Carbapenems
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Cephalosporins
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Culture Media
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Escherichia coli Proteins
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Recombinant Proteins
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beta-Lactamases
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beta-lactamase NDM-1
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Zinc