Bacteria in Asthma Pathogenesis

Michael Insel; Monica Kraft

doi:10.1016/j.iac.2019.03.006

Bacteria in Asthma Pathogenesis

Immunol Allergy Clin North Am. 2019 Aug;39(3):377-389. doi: 10.1016/j.iac.2019.03.006. Epub 2019 May 7.

Authors

Michael Insel¹, Monica Kraft²

Affiliations

¹ Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of Arizona Health Sciences, University of Arizona College of Medicine - Tucson, 1501 North Campbell Avenue, PO Box 245017, Tucson, AZ 85724, USA.
² Department of Medicine, College of Medicine Tucson, Asthma and Airway Disease Research Center, University of Arizona Health Sciences, University of Arizona College of Medicine - Tucson, 1501 North Campbell Avenue, PO Box 245017, Tucson, AZ 85724, USA. Electronic address: kraftm@email.arizona.edu.

PMID: 31284927
DOI: 10.1016/j.iac.2019.03.006

Abstract

The airways are under continuous assault from aerosolized bacteria and oral flora. The bacteria present in the airways and gastrointestinal tract of neonates promote immune maturation and protect against asthma pathogenesis. Later bacterial infections and perturbations to the microbiome can contribute to asthma pathogenesis, persistence, and severity.

Keywords: Asthma; Bacteria; Immunology; Microbiology.

Publication types

Review

MeSH terms

Animals
Anti-Bacterial Agents / adverse effects
Anti-Bacterial Agents / therapeutic use
Asthma / diagnosis
Asthma / etiology*
Bacterial Infections / complications*
Bacterial Infections / drug therapy
Bacterial Infections / immunology*
Bacterial Infections / microbiology
Disease Susceptibility* / immunology
Dysbiosis
Host-Pathogen Interactions* / immunology
Humans

Substances

Anti-Bacterial Agents