Application of various optical and electrochemical aptasensors for detection of human prostate specific antigen: A review

Biosens Bioelectron. 2019 Oct 1:142:111484. doi: 10.1016/j.bios.2019.111484. Epub 2019 Jul 2.

Abstract

Early stage detection of prostate cancer, one of the main causes of mortality among men, is of great importance for better treatment of the patients. Prostate specific antigen (PSA) is a glycoprotein which has been considered as the most potential serological biomarker for the detection of prostate cancer. Among the various techniques employed for PSA detection, aptamer-based biosensors (aptasensors) have achieved notable attention because of their unique features and great potentials as diagnostic tools. A variety of strategies such as integration of nanomaterials (NMs) into the structure of aptasensors have also been applied for enhancing the sensitivity of PSA detection. This article reviews recent advances in various optical and electrochemical aptasensors used for PSA detection.

Keywords: Aptamer; Aptasensor; Biosensor; Cancer biomarker; PSA.

Publication types

  • Review

MeSH terms

  • Animals
  • Aptamers, Nucleotide / chemistry*
  • Biosensing Techniques / instrumentation
  • Biosensing Techniques / methods*
  • Electrochemical Techniques / instrumentation
  • Electrochemical Techniques / methods
  • Equipment Design
  • Humans
  • Kallikreins / analysis
  • Kallikreins / blood*
  • Luminescent Measurements / instrumentation
  • Luminescent Measurements / methods
  • Male
  • Nanostructures / chemistry
  • Prostate-Specific Antigen / analysis
  • Prostate-Specific Antigen / blood*
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / diagnosis

Substances

  • Aptamers, Nucleotide
  • KLK3 protein, human
  • Kallikreins
  • Prostate-Specific Antigen