Cytotoxic 9,19-cycloartane Triterpenoids from the Roots of Actaea dahurica

Abstract

Eight undescribed 9,19-cycloartane type triterpenoid glycosides (cimdalglnoside A-H) and ten known analogues were obtained from the phytochemical research on the roots of Actaea dahurica (syn. Cimicifuga dahurica). All compounds were characterised by spectroscopic experiments, and chemical method. All the compounds isolated were assayed for cytotoxicity to five human cancer cell lines. Cimdalglnoside G showed promising cytotoxicities against Hela, and MCF-7 cell lines with IC₅₀ values at 7.7 and 12.2 μM.

Keywords: Actaea dahurica; Cycloartane; Cytotoxicity; Ranunculaceae; Triterpenoid glycoside.