Chemical constituents of Kopsia officinalis and their antagonizing high glucose-evoked podocyte injury activity

Fitoterapia. 2019 Sep:137:104258. doi: 10.1016/j.fitote.2019.104258. Epub 2019 Jul 5.

Abstract

Four new indole alkaloids (1-4) and twenty known compounds (5-24) were isolated from the leaves and stems, and fruits of Kopsia officinalis. Their structures were confirmed by means of spectroscopic methods. All these isolates were evaluated for their antagonizing high glucose-evoked podocyte injury activity for the first time, and compounds 5-8 showed potent activity with EC50 values of 3.0-12.0 μM.

Keywords: Diabetic nephropathy; Indole alkaloid; Kopsia officinalis; Podocyte injury.

MeSH terms

  • Animals
  • Apocynaceae / chemistry*
  • Cells, Cultured
  • China
  • Fruit / chemistry
  • Glucose
  • Indole Alkaloids / isolation & purification
  • Indole Alkaloids / pharmacology*
  • Mice
  • Molecular Structure
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Leaves / chemistry
  • Plant Stems / chemistry
  • Podocytes / drug effects*

Substances

  • Indole Alkaloids
  • Phytochemicals
  • Glucose