Transcribing Memories in Genome Architecture

Katherine R Tonn Eisinger; Anne E West

doi:10.1016/j.tins.2019.06.002

Transcribing Memories in Genome Architecture

Trends Neurosci. 2019 Sep;42(9):565-566. doi: 10.1016/j.tins.2019.06.002. Epub 2019 Jul 3.

Authors

Katherine R Tonn Eisinger¹, Anne E West²

Affiliations

¹ Duke University, Department of Neurobiology, Durham, NC 27710, USA.
² Duke University, Department of Neurobiology, Durham, NC 27710, USA. Electronic address: west@neuro.duke.edu.

PMID: 31279492
DOI: 10.1016/j.tins.2019.06.002

Abstract

Whether dynamic changes in genome architecture underlie transcriptional and functional plasticity in mature neurons has been technically challenging to address. A recent study (Yamada et al., Nature, 2019) exploited experimental advantages of the cerebellum to reveal cell type-specific changes in chromatin architecture that coordinate neural activity-induced changes in gene transcription and contribute to sensorimotor learning.

Keywords: chromatin; learning; transcription.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cerebellum
Chromatin
Learning
Memory*
Neuronal Plasticity*

Substances

Chromatin