The resting-brain of obsessive-compulsive disorder

Psychiatry Res Neuroimaging. 2019 Aug 30:290:38-41. doi: 10.1016/j.pscychresns.2019.06.008. Epub 2019 Jul 2.

Abstract

Obsessive-compulsive disorder (OCD) is one of the most debilitating psychiatric conditions, having a dramatic impact on patients' daily living. In this work, we aimed to explore resting-state functional connectivity in OCD patients, using an independent component analysis. Eighty individuals (40 patients and 40 healthy controls) performed a resting state fMRI protocol. OCD patients displayed reduced functional connectivity (FC) in visual and sensorimotor networks. In addition, patients displayed decreased FC between sensory networks and increased FC between default-mode and cerebellar networks.

Keywords: FMRI; Obsessive–compulsive disorder; Resting-state networks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain / diagnostic imaging
  • Brain / physiopathology
  • Brain Mapping / methods
  • Case-Control Studies
  • Cerebellum / diagnostic imaging
  • Cerebellum / physiopathology
  • Female
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Obsessive-Compulsive Disorder / diagnostic imaging
  • Obsessive-Compulsive Disorder / physiopathology*
  • Rest / physiology*