'PARAMEDIC-2: Big study, small result'

E Ter Avest; H Lameijer

doi:10.1007/s12471-019-1302-x

'PARAMEDIC-2: Big study, small result'

Neth Heart J. 2019 Jul;27(7-8):341-342. doi: 10.1007/s12471-019-1302-x.

Authors

E Ter Avest^{1

2}, H Lameijer³

Affiliations

¹ Department of Emergency Medicine, University Medical Center Groningen, Groningen, The Netherlands. e.ter.avest@umcg.nl.
² Air ambulance trust, Kent, Surrey and Sussex, Redhill airfield, Redhill, Surrey, UK. e.ter.avest@umcg.nl.
³ Department of Emergency Medicine, Medical Center Leeuwarden, Leeuwarden, The Netherlands.

Abstract

The PARAMEDIC-2 trial demonstrated that the use of adrenaline compared with placebo in out-of-hospital cardiac arrest (OHCA) resulted in a small increase in 30-day survival, but was associated with a higher number of survivors with severe neurological impairment. These findings received a lot of attention, and generated a widespread discussion about the role of adrenaline in cardiac arrest. In this point of view, we aim to place the PARAMEDIC-2 results in the right perspective by comparing the relative effect of adrenaline to other determinants of cerebral blood flow.

Keywords: Adrenaline; OHCA; Out-of-hospital cardiac arrest.

Publication types

Review