Lipid droplets (LDs) store energy-rich fatty acids (FAs), but to harvest them, LDs donate FAs to peroxisomes for oxidation. In this issue, Chang et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201902061) identify M1 Spastin as an LD-peroxisome tether that interacts with ESCRT-III components to facilitate lipid exchange between these two organelles.
© 2019 Henne.