Coronary vessel wall visualization via three-dimensional turbo spin-echo black blood imaging in Kawasaki disease

Koji Matsumoto; Hajime Yokota; Hiroki Mukai; Ryota Ebata; Naoki Saito; Kenji Shimokawa; Takafumi Yoda; Yoshitada Masuda; Takashi Uno; Tosiaki Miyati

doi:10.1016/j.mri.2019.07.001

Coronary vessel wall visualization via three-dimensional turbo spin-echo black blood imaging in Kawasaki disease

Magn Reson Imaging. 2019 Oct:62:159-166. doi: 10.1016/j.mri.2019.07.001. Epub 2019 Jul 2.

Authors

Koji Matsumoto¹, Hajime Yokota², Hiroki Mukai³, Ryota Ebata⁴, Naoki Saito⁵, Kenji Shimokawa⁶, Takafumi Yoda⁷, Yoshitada Masuda⁸, Takashi Uno⁹, Tosiaki Miyati¹⁰

Affiliations

¹ Department of Radiology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8677, Japan; Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 920-0942, Japan. Electronic address: matumoto@chiba-u.jp.
² Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8670, Japan. Electronic address: hjmykt@chiba-u.jp.
³ Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8670, Japan.
⁴ Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, Chiba 260-8670, Japan. Electronic address: eba-ryo@chiba-u.jp.
⁵ Department of Pediatrics, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba, Chiba 260-8670, Japan.
⁶ Department of Radiology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8677, Japan.
⁷ Department of Radiology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8677, Japan. Electronic address: t-yoda@chiba-u.jp.
⁸ Department of Radiology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8677, Japan. Electronic address: masuda.yoshitada@hospital.chiba-u.jp.
⁹ Diagnostic Radiology and Radiation Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Chiba 260-8670, Japan. Electronic address: unotakas@faculty.chiba-u.jp.
¹⁰ Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 920-0942, Japan. Electronic address: ramiyati@mhs.mp.kanazawa-u.ac.jp.

PMID: 31276758
DOI: 10.1016/j.mri.2019.07.001

Abstract

Purpose: To evaluate the feasibility of coronary vessel wall visualization using three-dimensional turbo spin-echo black blood imaging (3D-TSE) in children with Kawasaki disease.

Materials and methods: Nine patients (6 girls and 3 boys; mean age ± standard deviation, 5.6 ± 3.3 years; range, 1.4-10.3 years) were included. Coronary magnetic resonance angiography (MRA) with an axial slice orientation and 3D-TSE with axial and sagittal slice orientations (3D-TSE-axi and 3D-TSE-sag) were acquired for the whole heart. Coronary vessel walls were evaluated separately in aneurysm and normal-proximal regions. The internal diameter and wall thickness of the reformatted cross-sectional images were measured in both the regions. Reproducibility between MRA and 3D-TSE was evaluated via interclass correlation coefficients (ICCs) and Bland-Altman plots.

Results: In total, 164 points (aneurysmal regions, 73; normal-proximal regions, 64; normal-distal regions, 27) were evaluated. The ICC for 3D-TSE-axi was higher than that for 3D-TSE-sag (aneurysmal regions, ICC = 0.88 and 0.81; normal-proximal regions, ICC = 0.90 and 0.32, respectively). Bland-Altman plots of the internal diameter via MRA and 3D-TSE-axi showed a wide 95% limit of agreement (-0.13 to 2.89 mm) and significant fixed and proportional biases (P < 0.001 and P = 0.002) in the aneurysmal regions. However, the 95% limit of agreement was narrow (-0.14 to 0.57 mm) in the normal-proximal regions. If 1 mm was set as the cut-off for a thickened wall, wall thickness via 3D-TSE-axi was found to be abnormal across many points (84.0% of aneurysmal regions; 18.4% of normal-proximal regions).

Conclusions: 3D-TSE imaging of the normal-proximal regions of the coronary vessel in individuals with Kawasaki disease was found to be feasible. However, in aneurysmal regions, larger aneurysmal diameters led to an increased bias between MRA and 3D-TSE.

Keywords: Black blood imaging; Coronary artery; Kawasaki disease; Turbo spin-echo; Vessel wall imaging.

MeSH terms

Brain Mapping / methods
Child
Child, Preschool
Color
Coronary Vessels / diagnostic imaging*
Cross-Sectional Studies
Female
Humans
Image Processing, Computer-Assisted / methods
Imaging, Three-Dimensional*
Infant
Magnetic Resonance Angiography*
Male
Mucocutaneous Lymph Node Syndrome / diagnostic imaging*
Reproducibility of Results