Abstract
The rationale for a type 17 signature in the pathogenesis of spondyloarthritis (SpA) has been increasing and being ratified in studies recently. IL-7 is a cytokine whose ability to stimulate IL-17 production in both innate and adaptive immunity cells has made it a promising target not only for a better understanding of the disease as well as an important potential therapeutic target in patients with SpA.
MeSH terms
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Adaptive Immunity
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Animals
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Cytokines / genetics
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Cytokines / metabolism*
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Disease Susceptibility*
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Fibrosis
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Humans
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Immunity, Innate
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Interleukin-7 / genetics
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Interleukin-7 / metabolism*
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Protein Binding
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Receptors, Cytokine / metabolism
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Signal Transduction
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Spondylarthritis / etiology*
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Spondylarthritis / metabolism*
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Spondylarthritis / pathology
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T-Lymphocyte Subsets / immunology
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T-Lymphocyte Subsets / metabolism
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T-Lymphocyte Subsets / pathology
Substances
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Cytokines
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Interleukin-7
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Receptors, Cytokine