IL-7 is a Key Driver Cytokine in Spondyloarthritis?

J Immunol Res. 2019 May 29:2019:7453236. doi: 10.1155/2019/7453236. eCollection 2019.

Abstract

The rationale for a type 17 signature in the pathogenesis of spondyloarthritis (SpA) has been increasing and being ratified in studies recently. IL-7 is a cytokine whose ability to stimulate IL-17 production in both innate and adaptive immunity cells has made it a promising target not only for a better understanding of the disease as well as an important potential therapeutic target in patients with SpA.

Publication types

  • Review

MeSH terms

  • Adaptive Immunity
  • Animals
  • Cytokines / genetics
  • Cytokines / metabolism*
  • Disease Susceptibility*
  • Fibrosis
  • Humans
  • Immunity, Innate
  • Interleukin-7 / genetics
  • Interleukin-7 / metabolism*
  • Protein Binding
  • Receptors, Cytokine / metabolism
  • Signal Transduction
  • Spondylarthritis / etiology*
  • Spondylarthritis / metabolism*
  • Spondylarthritis / pathology
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / metabolism
  • T-Lymphocyte Subsets / pathology

Substances

  • Cytokines
  • Interleukin-7
  • Receptors, Cytokine